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Anti Androgen Treatment Medicine

Antiandrogens are the name given to a various gathering of prescriptions that check the impacts of the male sex hormones, testosterone and dihydrotestosterone. Male sex hormones are otherwise called androgens; antiandrogens may likewise be called androgen receptor blockers. Some antiandrogens work by bringing down the body's creation of androgens while others square androgen receptors, restricting the body's capacity to utilize the androgens delivered. Antiandrogens are utilized in the treatment of different conditions and disarranges including prostate malignant growth, gifted adolescence in youthful guys, generous prostatic hyperplasia, androgenic alopecia (male-design male pattern baldness) and sexual issue, for example, hyper-sexuality, in men. In ladies, antiandrogens might be utilized to treat polycystic ovary disorder, hirsutism (over the top facial or body hair), amenorrhea (nonattendance of menstrual periods), skin inflammation, and a few different conditions.

CYTOMID 250 MG

Code : DNC 578

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ENDACE 40 MG

Code : DNC 966

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Ant androgen drugs are a diverse group of medications given to counteract the effects of androgens (male sex hormones) on various body organs and tissues. Some medications in this category work by lowering the body’s production of androgens while others work by blocking the body’s ability to make use of the androgens that are produced. The first group of anti androgens includes such medications as Leuprolide (Lupron, Viadur, or Eligard), Goserelin (Zoladex), Triptorelin (Trelstar depot), and Abarelix (Plenaxis). These are very helpful in androgen treatment. The second group includes Flutamide (Eulexin), Nilutamide (Nilandron), Cyproterone acetate (Cyprostat, Androcur, Cyproterone), and Bicalutamide (Casodex). Flutamide, Nilutamide, and Bicalutamide are Nonsteroidal Anti Androgen medicines while Cyproterone acetate is a steroidal drug. These medicines are very effective and reliable in androgen deprivation therapy because doctors are always using these medicines in prostate cancer therapy. Androgen suppression therapy is common nowadays because it takes very less time to recover a patient from prostate cancer.  Some medicines that were originally designed to treat other conditions are sometimes categorized as Antiandrogens because their off-label uses include some of the main disorders listed below. These medicines such as Medroxyprogesterone (Depo-provera), a derivative of the female sex hormone progesterone that is widely used as a contraceptive and treatment for abnormal uterine bleeding, Ketoconazole (Nizoral), an antifungal medicines, and Spironolactonr (Aldactone) a diuretic.

 

Purpose of Antiandrogen Drugs:

Antiandrogen medicines may be used for any of several conditions or disorders, ranging from skin diseases to mental disorders.

  • Prostate cancer: Antiandrogen medication may be used to treat both early stage and advanced prostate cancer by lowering or blocking the supply of male sex hormones that encourage the growth and spread of the cancer. Androgen for prostate cancer nowadays has become a very effective and reliable way to treat moderate to severe conditions.  Anti androgen injections are much popular for the treatment of prostate cancer, so many doctor use the way injection because it provide relief in very fast way.
  • Androgentic alopecia: Androgenetic alopecia is a type of hair loss that is genetically determined and affects both men and women. It is sometimes called pattern baldness.
  • Acne: acne is the end result of several factors, one of which is excessive production of sebum, a whitish semi liquid greasy substance produced by certain glands in the skin. Antiandrogens drugs may help to clear acne from the face and back of the body by slowing down the secretion of sebum, which depends on androgen production.
  • Amenorrhea: Amenorrhea, or the absence of menstrual periods in women of childbearing age, is sometimes caused by excessively high levels of androgens in the blood. Anti androgen medications may be much more effective to restore normal menstrual periods.  It is widely used for high testosterone in female’s treatment a large number of doctors prescribed it to their patients.
  • Hirsutism: Hirsutism is a situation in which women produced excessive facial and body hair in a distribution pattern usually associated with adult males. It results from disorder high levels of androgens in the bloodstream or from increased sensitivity of the hair follicles to normal levels of androgens. Hirsutism may be a sign and signal of polycystic ovary syndrome (PCOS, a condition in which the ovaries generate multiple large cysts and produce too much androgen. So doctors are prescribed a medicine which helps patients in total androgen blockade because the excessive androgen became the cause of hirsutism.
  • Gender reassignment: Antiandrogen medicines are often recommended for male to female (MTF) transsexuals as part of the hormonal treatment that precedes gender reassignment operation.
  • Paraphilias: Paraphilias are a group of mental disorders characterized by intense and recurrent sexual urges or behaviors involving nonhuman things, children or no consenting adults, or pain and humiliation, Anti androgen medicines have been recommends for men treatment with Paraphlias in order to lower blood serum levels of testosterone and help them control their sexual urges.
  • Virilization: Virilization is an extreme form of hyperandrogenism in women, marked by such changes as development of male pattern baldness, voice changes, and overdevelopment of the skeletal muscles. Antiandrogens may be given to maintain this condition.

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List of Anti Androgens Drugs:

  • Leuprolide:
  • Goserelin
  • Triptorelin
  • Abarelix
  • Ketoconazole
  • Flutamide
  • Nilutamide
  • Bicalutamide
  • Cyproterone acetate
  • Medroxyprogesterone
  • Spironolactone etc.

Mechanism of action:

Anti Androgens are small molecules that compete with androgens to bind in the ligand binding site of the AR. Binding of antiandrogens , however, leads to unfavorable conformational changes, which down regulate transcription and so control the androgenic effects of normal binding.

 

Side Effects:

Anti-androgens may produce a range of common side effects, depending on the dose and type you consume.

 

Some possible side effects such as:

  • Low sex drive
  • Increased risk of depression
  • Elevated liver enzymes
  • Reduced facial and body hair
  • Higher risk of birth defect it taken during pregnancy
  • Liver injury
  • Breast tenderness
  • Hot flashes
  • Skin rash
  • Anti-androgen resistance, meaning the medication stops working etc

Your physician can help you choose an anti-androgen medicine that’s best suited for your needs and comes with the fewest side effects.

 

The bottom line:

Anti-androgens drugs have many uses for men, women, and people in gender transition, both on their own and in conjunction with other medications and treatments. However, anti-androgens medicines are powerful drugs that can cause some severe side effects. Discuss with your doctor to weight the pros and cons to taking anti-androgens.