Antiandrogens are the name given to a various gathering of prescriptions that check the impacts of the male sex hormones, testosterone and dihydrotestosterone. Male sex hormones are otherwise called androgens; antiandrogens may likewise be called androgen receptor blockers. Some antiandrogens work by bringing down the body's creation of androgens while others square androgen receptors, restricting the body's capacity to utilize the androgens delivered. Antiandrogens are utilized in the treatment of different conditions and disarranges including prostate malignant growth, gifted adolescence in youthful guys, generous prostatic hyperplasia, androgenic alopecia (male-design male pattern baldness) and sexual issue, for example, hyper-sexuality, in men. In ladies, antiandrogens might be utilized to treat polycystic ovary disorder, hirsutism (over the top facial or body hair), amenorrhea (nonattendance of menstrual periods), skin inflammation, and a few different conditions.
Ant androgen drugs are a diverse group of medications given to counteract the effects of androgens (male sex hormones) on various body organs and tissues. Some medications in this category work by lowering the body’s production of androgens while others work by blocking the body’s ability to make use of the androgens that are produced. The first group of anti androgens includes such medications as Leuprolide (Lupron, Viadur, or Eligard), Goserelin (Zoladex), Triptorelin (Trelstar depot), and Abarelix (Plenaxis). These are very helpful in androgen treatment. The second group includes Flutamide (Eulexin), Nilutamide (Nilandron), Cyproterone acetate (Cyprostat, Androcur, Cyproterone), and Bicalutamide (Casodex). Flutamide, Nilutamide, and Bicalutamide are Nonsteroidal Anti Androgen medicines while Cyproterone acetate is a steroidal drug. These medicines are very effective and reliable in androgen deprivation therapy because doctors are always using these medicines in prostate cancer therapy. Androgen suppression therapy is common nowadays because it takes very less time to recover a patient from prostate cancer. Some medicines that were originally designed to treat other conditions are sometimes categorized as Antiandrogens because their off-label uses include some of the main disorders listed below. These medicines such as Medroxyprogesterone (Depo-provera), a derivative of the female sex hormone progesterone that is widely used as a contraceptive and treatment for abnormal uterine bleeding, Ketoconazole (Nizoral), an antifungal medicines, and Spironolactonr (Aldactone) a diuretic.
Antiandrogen medicines may be used for any of several conditions or disorders, ranging from skin diseases to mental disorders.
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Anti Androgens are small molecules that compete with androgens to bind in the ligand binding site of the AR. Binding of antiandrogens , however, leads to unfavorable conformational changes, which down regulate transcription and so control the androgenic effects of normal binding.
Anti-androgens may produce a range of common side effects, depending on the dose and type you consume.
Your physician can help you choose an anti-androgen medicine that’s best suited for your needs and comes with the fewest side effects.
Anti-androgens drugs have many uses for men, women, and people in gender transition, both on their own and in conjunction with other medications and treatments. However, anti-androgens medicines are powerful drugs that can cause some severe side effects. Discuss with your doctor to weight the pros and cons to taking anti-androgens.